Disop Zero Liposomal Spray: the remedy for hyperevaporative dry eye disease


Most cases of dry eye syndrome are caused by hyperevaporation and are linked to a deterioration of the (outer) lipid layer of the tear film.

Hyperevaporative dry eye disease is associated with a meibomian gland dysfunction (MGD) or obstruction, which affects the thickness of the lipid layer. This results in greater evaporation of the aqueous layer and a subsequent destabilisation of the tear film and increased osmolarity (higher concentration of sodium chloride in the tear). This causes the symptoms of dry eye disease.


The deterioration of the lipid layer is what gives rise to hyperevaporative dry eye disease. That layer is made up of two sub-layers: the polar layer and the non-polar layer.

  • The inner polar layer (the finest of the two) is basically made up of phospholipids, such as phosphatidylcholine. This layer plays an essential role in stabilising the lipid structure of the outer non-polar layer.
  • That outer non-polar layer, which is there to prevent the evaporation of the aqueous layer, contains triglycerides, cholesterol and fatty acids.

Disop Zero Spray contains soy lecithin liposomes, which are largely made up of phosphatidylcholine. In the event of hyperevaporative dry eye disease, these liposomes enhance the thickness of the lipid layer and restore its anti evaporation function.